Synthesis, characterization, and anticancer activities of lipophilic pyridinecarboxaldimine platinum(II) complexes. (29th March 2016)

• Record Type: Journal Article
• Authors: Miles, Brittany A.; Patterson, Alyssa E.; Vogels, Christopher M.; Decken, Andreas; Waller, Jeffrey C.; Morin, Pier Jr.; Westcott, Stephen A.
• Is Part Of: Polyhedron. Volume 108(2016)
• Page Start: 23
• Page End: 29
• Publication Date: 2016-03-29
• Subjects: Anticancer -- Cytotoxicities -- Glioma -- Liophilicity -- Pyridinecarboxaldimines; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2015.07.039
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: Eleven platinum dichloride pyridinecarboxaldimine complexes containing aliphatic groups have been prepared and characterized fully. All platinum complexes were examined for their in vitro cytotoxic properties against two human glioblastoma multiforme cell lines LN18 and LN405. Abstract: We have prepared eleven pyridinecarboxaldimines (N-N'R) from the condensation of 2-pyridinecarboxaldehyde and the corresponding lipophilic primary amines. Addition of these ligands to [PtCl2 (η 2 -coe)]2 (coe = cis-cyclooctene) gave complexes of the type cis-PtCl2 (N-N'R) (2a -k ) in moderate to high yields. The molecular structure of the N-butylphenyl derivative (2h ) has been confirmed by an X-ray diffraction study. Crystals of2h were monoclinic with a = 8.5414(9) Å, b = 11.6774(12) Å, c = 16.1235(16) Å, β = 92.7610(10)° in the space group P 2(1)/ c . All platinum complexes were examined for their in vitro cytotoxic properties against two human glioblastoma multiforme cell lines LN18 and LN405. The DNA binding properties of one of the most cytotoxic compounds was compared with that of cisplatin, but no effect was observed under the conditions tested.