Comparison of predictive accuracy of teicoplanin concentration using creatinine clearance and glomerular filtration rate estimated by serum creatinine or cystatin C. Issue 5 (May 2016)

• Record Type: Journal Article
• Authors: Kozono, Aki; Hiraki, Yoichi; Adachi, Rui; Nagano, Masahisa; Inoue, Daisuke; Tsuji, Yasuhiro; Kamimura, Hidetoshi; Karube, Yoshiharu
• Is Part Of: Journal of infection and chemotherapy. Volume 22:Issue 5(2016:May)
• Page Start: 314
• Page End: 318
• Publication Date: 2016-05
• Subjects: Cockcroft–Gault equation -- Cystatin C -- Hoek equation -- Predictive accuracy -- Serum creatinine -- Teicoplanin; Chemotherapy -- Periodicals; Infection -- Periodicals; Communicable diseases -- Chemotherapy -- Periodicals; 615.5805
• DOI: 10.1016/j.jiac.2016.01.024
• Languages: English
• ISSNs: 1341-321X

Abstract

Abstract: We compared the predictive accuracy of TEIC concentrations (TEIC _conc ) calculated using either serum cystatin C (CysC) or serum creatinine (SCr) and the population mean method using the mean population parameter of TEIC _conc for Japan. We also compared the predicted TEIC _conc to measured TEIC _conc . Creatinine clearance (CLCr) predicted using the Cockcroft–Gault (C&G) equation with SCr was 45.23 mL/min (interquartile range [IQR]: 32.12–58.28), and the glomerular filtration rate (GFR) predicted using the Hoek equation with CysC was 45.23 mL/min (IQR: 35.40–53.79). The root mean-squared prediction error (IQR) based on CLCr predicted using the C&G equation with SCr was 6.88 (3.80–9.96) μg/mL, and that based on GFR predicted using the Hoek equation with CysC was 6.72 (3.77–9.68) μg/mL. Predicted TEIC _conc did not differ significantly between the two methods. The predictive accuracy of the TEIC _conc using the Hoek equation with CysC was similar to that of CLCr using the C&G equation with SCr. These findings suggest that the predictive accuracy of the TEIC _conc using CLCr based on the G&G equation and SCr might be sufficient for the initial dose adjustment of TEIC. Given that we were unable to confirm that CysC is the optimal method for predicting TEIC _conc, the expensive measurement of CysC might not be necessary.