Application of atelocollagen sheet for sellar reconstruction. (May 2016)

• Record Type: Journal Article
• Authors: Goto, Yuko; Oshino, Satoru; Shimizu, Takeshi; Saitoh, Youichi
• Is Part Of: Journal of clinical neuroscience. Volume 27(2016:May)
• Page Start: 142
• Page End: 146
• Publication Date: 2016-05
• Subjects: Atelocollagen -- Cerebrospinal leakage -- Fibrin glue sealant -- Sellar reconstruction; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2015.08.039
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: We investigated effectiveness of atelocollagen sheet with fibrin glue sealant for sellar reconstraction. We examine adhesive properties and histological changes induced by using the combination of atelocollagen sheet and fibrin glue. Atelocollagen sheet had sufficient pressure resistance and tissue affinity in addition to its hemostatic effect. Atelocollagen sheet is consider to be an effective material for sellar reconstruction. Abstract: We aimed to evaluate combined use of atelocollagen sheet and fibrin glue for sellar reconstruction. Experiment 1: A plastic chamber was prepared with a hydroxyapatite lid with a hole of 10 mm in diameter at its center, covered with a Gore-Tex sheet (W.L. Gore & Associates, Tokyo, Japan) 15 mm in diameter and sealed with a combination of fibrin glue sealant and either atelocollagen sheet or polyglycolic acid (PGA) sheet. Air was injected into the chamber and the pressure at which air leakage occurred was measured under each situation. Mean (± standard deviation) leakage pressure was 816 ± 162 mmH2 O for atelocollagen sheet (n = 5), significantly higher than the 557 ± 130 mmH2 O for PGA sheet (n = 5, p < 0.05, Wilcoxon test). Experiment 2: Bilateral 5 mm bone windows were made in the temporal bone in eight rats. The surgical cavities were filled with one of four materials (fibrin glue only; fibrin glue and atelocollagen sheet; PGA sheet; or autologous fat tissue). Histological changes including the status of implanted materials and inflammatory responses were investigated 2 and 5 weeks after the procedures. Both atelocollagen and PGA sheets remained at 5 weeks after implantation, whereas fibrin glue and fat tissue were absorbed and undetectable at 2 weeks. Inflammatory cell accumulation was less around the atelocollagen sheet compared to the PGA sheet. The combination of atelocollagen sheet and fibrin glue sealant showed sufficient adhesion force and favorable tissue affinity, suggesting this combination as a feasible material in sellar reconstruction.