A palladium-catalyzed coupling reaction of aryl nonaflates, sulfur dioxide, and hydrazines. Issue 5 (24th December 2015)

• Record Type: Journal Article
• Authors: An, Yuanyuan; Xia, Hongguang; Wu, Jie
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 5(2016)
• Page Start: 1665
• Page End: 1669
• Publication Date: 2015-12-24
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob02514a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A facile route to synthesise N -aminosulfonamides through a palladium-catalyzed coupling reaction of aryl nonaflates, sulfur dioxide, and hydrazines is reported. This transformation proceeds in the presence of Pd(OAc)2 /XantPhos, and TBAB in 1, 4-dioxane at 80 °C, leading to the corresponding N -aminosulfonamides in moderate to good yields. Abstract : A facile route to synthesise N -aminosulfonamides through a palladium-catalyzed coupling reaction of aryl nonaflates, sulfur dioxide, and hydrazines is reported. This transformation proceeds in the presence of Pd(OAc)2 /XantPhos, and TBAB in 1, 4-dioxane at 80 °C, leading to the corresponding N -aminosulfonamides in moderate to good yields. The reaction scope has been demonstrated, and good functional tolerance is observed. A plausible mechanism is proposed through the insertion of sulfur dioxide.