Digital breast tomosynthesis (3D-mammography) screening: A pictorial review of screen-detected cancers and false recalls attributed to tomosynthesis in prospective screening trials. (April 2016)

• Record Type: Journal Article
• Authors: Houssami, Nehmat; Lång, Kristina; Bernardi, Daniela; Tagliafico, Alberto; Zackrisson, Sophia; Skaane, Per
• Is Part Of: Breast. Volume 26(2016)
• Page Start: 119
• Page End: 134
• Publication Date: 2016-04
• Subjects: Breast cancer detection -- Cancer screening -- Digital breast tomosynthesis -- False-positive recall -- Mammography -- Population screening; Breast -- Diseases -- Periodicals; Breast -- Tumors -- Periodicals; Breast -- Periodicals; Electronic journals; Periodicals; 616
• DOI: 10.1016/j.breast.2016.01.007
• Languages: English
• ISSNs: 0960-9776

Abstract

Abstract: This pictorial review highlights cancers detected only at tomosynthesis screening and screens falsely recalled in the course of breast tomosynthesis screening, illustrating both true-positive (TP) and false-positive (FP) detection attributed to tomosynthesis. Images and descriptive data were used to characterise cases of screen-detection with tomosynthesis, sourced from prospective screening trials that performed standard (2D) digital mammography (DM) and tomosynthesis (3D-mammography) in the same screening participants. Exemplar cases from four trials highlight common themes of relevance to screening practice including: the type of lesions frequently made more conspicuous or perceptible by tomosynthesis (spiculated masses, and architectural distortions); the histologic findings (both TP and FP) of tomosynthesis-only detection; and the need to extend breast work-up protocols (additional imaging including ultrasound and MRI, and tomosynthesis-guided biopsy) if tomosynthesis is adopted for primary screening. Highlights: Exemplar cases from prospective tomosynthesis screening trials highlight common themes on the type of lesions made more conspicuous or perceptible by tomosynthesis. Case-based review illustrating cancers detected, and also false-positives, from using tomosynthesis in first (prevalent) population screening rounds. Describes extension of breast work-up protocols to evaluate tomosynthesis-detected findings.