The PCSK6 gene is associated with handedness, the autism spectrum, and magical ideation in a non-clinical population. (April 2016)

• Record Type: Journal Article
• Authors: Robinson, Kelsey J.; Hurd, Peter L.; Read, Silven; Crespi, Bernard J.
• Is Part Of: Neuropsychologia. Volume 84(2016)
• Page Start: 205
• Page End: 212
• Publication Date: 2016-04
• Subjects: Handedness -- Lateralization -- PCSK6 gene -- VNTR -- Autism -- Schizotypy; Neuropsychology -- Periodicals; Neurology -- Periodicals; Psychophysiology -- Periodicals; Neuropsychologie -- Périodiques; Neuropsychology; Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.neuropsychologia.2016.02.020
• Languages: English
• ISSNs: 0028-3932

Abstract

Abstract: Common polymorphisms in the gene PCSK6, whose protein product mediates the development of brain and body asymmetry through the NODAL pathway, have recently been associated with handedness in three studies, making it a key candidate gene for understanding the developmental and expression of human lateralization. We tested the hypothesis that the PCSK6 VNTR polymorphism rs1053972 influences the expression of handedness and aspects of dimensional schizotypy and autism. For a sample of 709 healthy individuals, rs1053972 genotype was significantly associated with categorical measures of handedness, and with dimensional handedness in subsets of the population with high schizotypy and magical ideation or a lack of strong right-handedness. Both findings showed evidence of stronger or exclusive effects among females, compared to males. Genotypes of PCSK6 also showed significant sex-limited associations with magical ideation, a component of positive schizotypal cognition measured using the Schizotypal Personality Questionnaire, and total autism score, measured using the Autism Spectrum Quotient. These results partially replicate previous studies on effects of PCSK6 rs1053972 genetic variation on handedness phenotypes, link the PCSK6 gene with the dimensional expression of neurodevelopmental conditions in healthy individuals, and show that associations of this gene with handedness and psychological phenotypes exhibit evidence of sex-limited effects. Highlights: The PCSK6 gene represents a primary candidate gene for human handedness. The PCSK6 VNTR rs1053972 was linked with handedness in a healthy population. VNTR rs1053972 genotype was associated with autism and schizotypy. Variation in PCSK6 exhibits effects on both handedness and psychological traits.