Raman spectroscopy as a diagnostic tool for monitoring acute nephritis. Issue 3 (21st May 2015)

• Record Type: Journal Article
• Authors: Li, Jingting; Du, Yong; Qi, Ji; Sneha, Ravikumar; Chang, Anthony; Mohan, Chandra; Shih, Wei‐Chuan
• Is Part Of: Journal of biophotonics. Volume 9:Issue 3(2016)
• Page Start: 260
• Page End: 269
• Publication Date: 2015-05-21
• Subjects: anti‐glomerular basement membrane nephritis -- acute nephritis -- optical diagnosis -- Raman spectroscopy -- principal component analysis -- linear discriminant analysis; Photonics -- Periodicals; Optical materials -- Periodicals; Optics -- Periodicals; Medical instruments and apparatus -- Periodicals; 621.3605
• DOI: 10.1002/jbio.201500109
• Languages: English
• ISSNs: 1864-063X

Abstract

Abstract : Both acute nephritis and chronic nephritis account for substantial morbidity and mortality worldwide, partly due to the lack of reliable tools for detecting disease early and monitoring its progression non‐invasively. In this work, Raman spectroscopy coupled with multivariate analysis are employed for the first time to study the accelerated progression of nephritis in anti‐GBM mouse model. Preliminary results show up to 98% discriminant accuracy for the severe and midly diseased and the healthy among two strains of mice with different susceptibility to acute glomerulonephritis. This technique has the potential for non‐invasive or minimally‐invasive early diagnosis, prognosis, and monitoring of renal disease progression. Abstract : Raman spectroscopy combined with multivariate analysis are employed for the first time to study the accelerated progression of nephritis in anti‐GBM mouse model. Preliminary results show up to 98% discriminant accuracy for the severely and mildly diseased and the healthy among two strains of mice with different susceptibility to acute glomerulonephritis. This technique has the potential for non‐invasive or minimally‐invasive early diagnosis, prognosis, and monitoring of renal disease progression.