Purinergic signalling-evoked intracellular Ca2+ concentration changes in the regulation of chondrogenesis and skeletal muscle formation. Issue 2 (March 2016)

• Record Type: Journal Article
• Authors: Matta, Csaba; Fodor, János; Csernoch, László; Zákány, Róza
• Is Part Of: Cell calcium. Volume 59:Issue 2/3(2016)
• Page Start: 108
• Page End: 116
• Publication Date: 2016-03
• Subjects: AC adenylate cyclase -- ATSC adipose tissue-derived stem cell -- CPC chondrogenic progenitor cell -- DFC dental follicle cell -- ECM extracellular matrix -- ERK extracellular signal-regulated protein kinase -- FGF fibroblast growth factor -- GPCR G-protein coupled receptor -- HDC high density cultures -- IP3 inositol 1, 4, 5-trisphosphate -- MRF myogenic regulatory factor -- MSC mesenchymal stem cell -- MSK musculoskeletal -- NFAT nuclear factor of activated T lymphocytes -- NMDA N-methyl-D-aspartate type ionotropic glutamate receptor -- PI3-K phosphoinositide 3-kinase -- PLC phospholipase C -- PP2B protein phosphatase 2B (calcineurin) -- RyR ryanodine receptor -- SERCA sarcoplasmic/endoplasmic Ca2+-ATPase -- Shh sonic hedgehog -- SOCE store operated calcium entry -- TGF transforming growth factor -- TRP transient receptor potential channel; Cartilage formation -- Myogenesis -- Mesenchymal stem cells -- Purinoreceptor -- ATP -- Ca-oscillations; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2016.01.006
• Languages: English
• ISSNs: 0143-4160

Abstract

Graphical abstract: Highlights: Precisely set intracellular Ca 2+ -concentration changes regulate chondrogenesis. Elements of purinergic signalling are expressed in immature cartilage and muscle. Ectopurines evoke intracellular Ca 2+ -events during muscle and cartilage formation. Various functions of chondrocytes are altered by Ca 2+ -concentration changes. Cell proliferation is very sensitive to properly set intracellular Ca 2+ -events Abstract: It is now widely recognised that changes of the intracellular calcium concentration have deep impact on the differentiation of various non-excitable cells including the elements of the vertebrate skeleton. It has become evident that purinergic signalling is one of the most ancient cellular mechanisms that can cause such alterations in the intracellular Ca 2+ -homeostasis, which are precisely set either spatially or temporally. Purinergic signalling is believed to regulate intracellular Ca 2+ -concentration of developing cartilage and skeletal muscle cells and suggested to play roles in the modulation of various cellular functions. This idea is supported by the fact that pluripotent mesenchymal cells, chondroprogenitors or muscle precursors, as well as mature chondrocytes all are capable of releasing ectonucleotides, and express various types of purinoreceptors and ectonucleotidases. The presence of the basic components of purinergic signalling proves that cells of the chondrogenic lineage can utilise this mechanism for modulating their intracellular Ca 2+ concentration independently from the surrounding skeletal muscle and bone tissues, which are well known to release ectopurines during development and mechanical stress. In this review, we summarize accumulating experimental evidence supporting the importance of purinergic signalling in the regulation of chondrogenesis and during skeletal muscle formation.