Vasopressin-induced Ca2+ signals in human adipose-derived stem cells. Issue 2 (March 2016)

• Record Type: Journal Article
• Authors: Tran, Tran Doan Ngoc; Gimble, Jeffrey M.; Cheng, Henrique
• Is Part Of: Cell calcium. Volume 59:Issue 2/3(2016)
• Page Start: 135
• Page End: 139
• Publication Date: 2016-03
• Subjects: Human adipose-derived stem cells -- Arginine vasopressin -- Ca2+ signaling -- Differentiation; AVP arginine vasopressin -- hASCs human adipose-derived stromal/stem cells -- hBMSCs human bone marrow-derived stromal/stem cells -- cAMP cyclic adenosine monophosphate -- C/EBP CCAAT/enhancer-binding protein -- CFU colony forming unit -- CRAC Ca2+ release-activated Ca2+ channels -- ER endoplasmic reticulum -- ERK extracellular signal-regulated kinase -- ESCs embryonic stem cells -- FABP4 fatty acid binding protein 4 -- IP3 inositol-1, 4, 5-triphosphate -- MAPK mitogen-activated protein kinase -- miRNA micro-ribonucleic acid -- MLR mixed lymphocyte reaction -- PI3K/Akt/mTOR phosphoinositide-3-kinase/Akt/mammalian target of rapamycin -- PIP2 phosphatidylinositol-4, 5-biphosphate -- PLC phospholipase C -- PKA protein kinase A -- PPARγ peroxisome proliferator-activated receptor γ -- SOCs store-operated Ca2+ channels -- STIM stromal interaction molecule -- SVF stromal vascular fraction -- TRPM7 transient receptor potential melastatin 7 -- TRPV transient receptor potential vanilloid -- VDCCs voltage-dependent Ca2+ channels; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2015.12.006
• Languages: English
• ISSNs: 0143-4160

Abstract

Graphical abstract: Highlights: hASCs are multipotent cells that can differentiate into many cell types. hASCs have V1a receptors and respond to AVP during adipocyte differentiation. AVP signaling increases intracellular Ca 2+ via the Gq–PLC–IP3 pathway. Both Ca 2+ influx and release from the endoplasmic reticulum are the Ca 2+ sources. AVP inhibits adipogenesis. Abstract: Intracellular Ca 2+ signals are essential for stem cell differentiation due to their ability to control signaling pathways involved in this process. Arginine vasopression (AVP) is a neurohypophyseal hormone that increases intracellular Ca 2+ concentration during adipogenesis via V1a receptors, Gq-proteins and the PLC–IP3 pathway in human adipose-derived stromal/stem cells (hASCs). These Ca 2+ signals originate through calcium release from pools within the endoplasmic reticulum and the extracellular space. AVP supplementation to the adipogenic media inhibits adipogenesis and key adipocyte marker genes. This review focuses on the intersection between AVP, Ca 2+ signals and ASC differentiation.