Inside Back Cover: Generation of Complex Azabicycles and Carbobicycles from Two Simple Compounds in a Single Operation through a Metal‐Free Six‐Step Domino Reaction (Chem. Eur. J. 15/2016). Issue 15 (25th February 2016)

• Record Type: Journal Article
• Authors: Bock, Christina M.; Parameshwarappa, Gangajji; Bönisch, Simon; Neiss, Christian; Bauer, Walter; Hampel, Frank; Görling, Andreas; Tsogoeva, Svetlana B.
• Is Part Of: Chemistry. Volume 22:Issue 15(2016)
• Page Start: 5431
• Page End: 5431
• Publication Date: 2016-02-25
• Subjects: antiviral agents -- density functional calculations -- domino reaction -- organocatalysis -- medicinal chemistry; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201600644
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : An unprecedented metal‐free two component six‐step domino reaction, which provides a straightforward and atom‐economical route to bioactive azabicycles and carbobicycles, has been developed. The studies were supported by mechanistic investigations of the chemoselective branching step by using DFT methods, accounting for dispersion interactions. This new domino reaction allows the generation, in a single operation, of new artemisinin‐derived hybrid compounds with strong antiviral properties outperforming the clinically used drug ganciclovir. More information can be found in the Full Paper by A. Görling, S. B. Tsogoeva et al. onpage 5189 ff.