Asymmetric Synthesis of Axinellamines A and B. Issue 15 (8th March 2016)

• Record Type: Journal Article
• Authors: Ma, Zhiqiang; Wang, Xiao; Ma, Yuyong; Chen, Chuo
• Is Part Of: Angewandte Chemie international edition. Volume 55:Issue 15(2016)
• Page Start: 4763
• Page End: 4766
• Publication Date: 2016-03-08
• Subjects: alkaloids -- anchimeric assistance -- axinellamines -- natural products -- total synthesis; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201600007
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Axinellamines A and B are broad‐spectrum antibacterial pyrrole–imidazole alkaloids that have a complex polycyclic skeleton. A new asymmetric synthesis of these marine sponge metabolites is described herein, featuring an oxidative rearrangement and an anchimeric chlorination reaction. Abstract : From start to end : Axinellamines A and B are two dimeric pyrrole–imidazole alkaloids that have unusually high nitrogen and halogen atom contents. An asymmetric synthesis of these structurally complex natural antibiotics is described.