Association of Body Composition and Hormonal and Inflammatory Factors With Tibial Cartilage Volume and Sex Difference in Cartilage Volume in Young Adults. Issue 4 (24th March 2016)

• Record Type: Journal Article
• Authors: Antony, Benny; Venn, Alison; Cicuttini, Flavia; March, Lyn; Blizzard, Leigh; Dwyer, Terence; Cross, Marita; Jones, Graeme; Ding, Changhai
• Is Part Of: Arthritis care & research. Volume 68:Issue 4(2016:Apr.)
• Page Start: 517
• Page End: 525
• Publication Date: 2016-03-24
• Subjects: Arthritis -- Periodicals; Rheumatism -- Periodicals; 616.72
• DOI: 10.1002/acr.22715
• Languages: English
• ISSNs: 2151-464X

Abstract

Abstract : Objective: To describe the associations between body composition and hormonal and inflammatory factors measured 5 years prior and tibial cartilage volume in young adults, and to explore if these factors contribute to the sex difference in tibial cartilage volume. Methods: Subjects broadly representative of the young adult Australian population (n = 328, ages 31–41 years, 47.3% women) were selected. They underwent T1‐weighted fat‐suppressed magnetic resonance imaging (MRI) of their knees. Tibial cartilage volume was measured from MRI. Sex hormone binding globulin (SHBG) and testosterone in a subset of women and C‐reactive protein (CRP) level and fibrinogen in both sexes were measured 5 years prior. Body mass index (BMI), fat mass, and lean mass were calculated from height, weight, and skinfolds. Results: In multivariable analyses, correlates of tibial cartilage volume included lean body mass (β = 26.4 mm 3 ; 95% confidence interval [95% CI] 13.6, 39.1), fat mass (β = −11.8 mm 3 ; 95% CI −22.2, −1.4), and fibrinogen (β = −146.4 mm 3 ; 95% CI −276.4, −16.4), but not BMI, testosterone, or CRP level. In women, SHBG was positively associated with tibial cartilage volume (β = 0.67 mm 3 ; 95% CI 0.14, 1.20) and Free Androgen Index was negatively associated with lateral tibial cartilage volume (β = −0.04 mm 3 ; 95% CI −0.07, 0.00). Men had 13% more tibial cartilage volume (500 mm 3 ) than women. The magnitude of this association decreased by 38%, 20%, and 37% after adjustment for lean body mass, fat mass, and fibrinogen, respectively. Conclusion: Body composition, sex hormones, and fibrinogen correlate with knee cartilage volume in young adult life. Sex difference in knee cartilage volume is contributed largely by variations in body composition and/or fibrinogen.