Promoting intestinal adaptation by nutrition and medication. Issue 2 (April 2016)

• Record Type: Journal Article
• Authors: Neelis, E.G.; Olieman, J.F.; Hulst, J.M.; de Koning, B.A.E.; Wijnen, R.M.H.; Rings, E.H.H.M.
• Is Part Of: Best practice & research. Volume 30:Issue 2(2016)
• Page Start: 249
• Page End: 261
• Publication Date: 2016-04
• Subjects: Enteral nutrition -- Growth factors -- Intestinal adaptation -- Intestinal failure -- Parenteral nutrition -- Short bowel syndrome; EN Enteral nutrition -- GH Growth hormone -- GLP-1 Glucagon-like peptide-1 -- GLP-2 Glucagon-like peptide-2 -- HGF Hepatocyte growth factor -- IGF Insulin-like growth factor -- IF Intestinal failure -- LCPs Long chain polyunsaturated fatty acids -- LCTs Long chain triglycerides -- MCTs Medium chain triglycerides -- PN Parenteral nutrition -- PPIs Proton pomp inhibitors -- SBS Short bowel syndrome -- SCFAs Short chain fatty acids -- SIBO Small intestinal bacterial overgrowth; Gastroenterology -- Periodicals; Gastrointestinal system -- Diseases -- Periodicals; Gastrointestinal Diseases; Gastroenterology; Klinische geneeskunde; Gastro-enterologie; Gastroenterology; Gastrointestinal system -- Diseases; Periodicals; 616.33005
• DOI: 10.1016/j.bpg.2016.03.002
• Languages: English
• ISSNs: 1521-6918

Abstract

Abstract: The ultimate goal in the treatment of short bowel syndrome is to wean patients off parenteral nutrition, by promoting intestinal adaptation. Intestinal adaptation is the natural compensatory process that occurs after small bowel resection. Stimulating the remaining bowel with enteral nutrition can enhance this process. Additionally, medication can be used to either reduce factors that complicate the adaptation process or to stimulate intestinal adaptation, such as antisecretory drugs and several growth factors. The aim of this review was to provide an overview of the best nutritional strategies and medication that best promote intestinal adaptation.