Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09‐related pneumonia: an individual participant data meta‐analysis. Issue 3 (1st February 2016)

• Record Type: Journal Article
• Authors: Muthuri, Stella G.; Venkatesan, Sudhir; Myles, Puja R.; Leonardi‐Bee, Jo; Lim, Wei Shen; Al Mamun, Abdullah; Anovadiya, Ashish P.; Araújo, Wildo N.; Azziz‐Baumgartner, Eduardo; Báez, Clarisa; Bantar, Carlos; Barhoush, Mazen M.; Bassetti, Matteo; Beovic, Bojana; Bingisser, Roland; Bonmarin, Isabelle; Borja‐Aburto, Victor H.; Cao, Bin; Carratala, Jordi; Cuezzo, María R.; Denholm, Justin T.; Dominguez, Samuel R.; Duarte, Pericles A. D.; Dubnov‐Raz, Gal; Echavarria, Marcela; Fanella, Sergio; Fraser, James; Gao, Zhancheng; Gérardin, Patrick; Giannella, Maddalena; Gubbels, Sophie; Herberg, Jethro; Higuera Iglesias, Anjarath L.; Hoeger, Peter H.; Hoffmann, Matthias; Hu, Xiaoyun; Islam, Quazi T.; Jiménez, Mirela F.; Kandeel, Amr; Keijzers, Gerben; Khalili, Hossein; Khandaker, Gulam; Knight, Marian; Kusznierz, Gabriela; Kuzman, Ilija; Kwan, Arthur M. C.; Lahlou Amine, Idriss; Langenegger, Eduard; Lankarani, Kamran B.; Leo, Yee‐Sin; Linko, Rita; Liu, Pei; Madanat, Faris; Manabe, Toshie; Mayo‐Montero, Elga; McGeer, Allison; Memish, Ziad A.; Metan, Gokhan; Mikić, Dragan; Mohn, Kristin G. I.; Moradi, Ahmadreza; Nymadawa, Pagbajabyn; Ozbay, Bulent; Ozkan, Mehpare; Parekh, Dhruv; Paul, Mical; Poeppl, Wolfgang; Polack, Fernando P.; Rath, Barbara A.; Rodríguez, Alejandro H.; Siqueira, Marilda M.; Skręt‐Magierło, Joanna; Talarek, Ewa; Tang, Julian W.; Torres, Antoni; Törün, Selda H.; Tran, Dat; Uyeki, Timothy M.; van Zwol, Annelies; Vaudry, Wendy; Velyvyte, Daiva; Vidmar, Tjasa; Zarogoulidis, Paul; Nguyen‐Van‐Tam, Jonathan S.;
• Other Names: de Lourdes Aguiar‐Oliveira Maria investigator.; Al Khuwaitir Tarig SA investigator.; Al Masri Malakita investigator.; Amin Robed investigator.; Ballester‐Orcal Elena investigator.; Bao Jing investigator.; Basher Ariful investigator.; Bautista Edgar investigator.; Bertisch Barbara investigator.; Bettinger Julie investigator.; Booy Robert investigator.; Bouza Emilio investigator.; Bozkurt Ilkay investigator.; Burgmann Heinz investigator.; Čeljuska‐Tošev Elvira investigator.; Chan Kenny KC investigator.; Chen Yusheng investigator.; Chinbayar Tserendorj investigator.; Cilloniz Catia investigator.; Cox Rebecca J investigator.; Sarrouf Elena B investigator.; Cui Wei investigator.; Dashti‐Khavidaki Simin investigator.; Du Bin investigator.; El Rhaffouli Hicham investigator.; Escobar Hernan investigator.; Florek‐Michalska Agnieszka investigator.; Gerrard John investigator.; Gormley Stuart investigator.; Götberg Sandra investigator.; Honarvar Behnam investigator.; Hu Jianming investigator.; Kemen Christoph investigator.; Koay Evelyn SC investigator.; Kojic Miroslav investigator.; Kudo Koichiro investigator.; Kyaw Win M investigator.; Leibovici Leonard investigator.; Li Xiao‐li investigator.; Li Hongru investigator.; Libster Romina investigator.; Loh Tze P investigator.; Macbeth Deborough investigator.; Maltezos Efstratios investigator.; Marcone Débora N investigator.; Marczynska Magdalena investigator.; Mastalir Fabiane P investigator.; Mickiene Auksė investigator.; Moghadami Mohsen investigator.; Moriconi Lilian investigator.; Oliva Maria E investigator.; Pečavar Blaž investigator.; Poliquin Philippe G investigator.; Rahman Mahmudur investigator.; Rascon‐Pacheco Alberto investigator.; Refaey Samir investigator.; Schweiger Brunhilde investigator.; Seale Anna C investigator.; Sertogullarindan Bunyamin investigator.; Smith Fang G investigator.; Somer Ayper investigator.; Souza Thiago ML investigator.; Stephan Frank investigator.; Tabarsi Payam investigator.; Tripathi CB investigator.; Viasus Diego investigator.; Yu Qin investigator.; Zhang Wei investigator.; Zuo Wei investigator.;
• Is Part Of: Influenza and other respiratory viruses. Volume 10:Issue 3(2016)
• Page Start: 192
• Page End: 204
• Publication Date: 2016-02-01
• Subjects: Hospitalisation -- individual participant data meta‐analyses -- influenza‐related pneumonia -- neuraminidase inhibitors; Influenza -- Periodicals; Respiratory infections -- Periodicals; Virus diseases -- Periodicals; Influenza, Human -- Periodicals; Respiratory Tract Diseases -- Periodicals; Virus Diseases -- Periodicals; Grippe -- Périodiques; Appareil respiratoire -- Infections -- Périodiques; Maladies à virus -- Périodiques; 616.203
• DOI: 10.1111/irv.12363
• Languages: English
• ISSNs: 1750-2640

Abstract

Abstract : Background: The impact of neuraminidase inhibitors (NAIs) on influenza‐related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection. Methods: A worldwide meta‐analysis of individual participant data from 20 634 hospitalised patients with laboratory‐confirmed A(H1N1)pdm09 ( n = 20 021) or clinically diagnosed ( n = 613) 'pandemic influenza'. The primary outcome was radiologically confirmed IRP. Odds ratios (OR) were estimated using generalised linear mixed modelling, adjusting for NAI treatment propensity, antibiotics and corticosteroids. Results: Of 20 634 included participants, 5978 (29·0%) had IRP; conversely, 3349 (16·2%) had confirmed the absence of radiographic pneumonia (the comparator). Early NAI treatment (within 2 days of symptom onset) versus no NAI was not significantly associated with IRP [adj. OR 0·83 (95% CI 0·64–1·06; P = 0·136)]. Among the 5978 patients with IRP, early NAI treatment versus none did not impact on mortality [adj. OR = 0·72 (0·44–1·17; P = 0·180)] or likelihood of requiring ventilatory support [adj. OR = 1·17 (0·71–1·92; P = 0·537)], but early treatment versus later significantly reduced mortality [adj. OR = 0·70 (0·55–0·88; P = 0·003)] and likelihood of requiring ventilatory support [adj. OR = 0·68 (0·54–0·85; P = 0·001)]. Conclusions: Early NAI treatment of patients hospitalised with A(H1N1)pdm09 virus infection versus no treatment did not reduce the likelihood of IRP. However, in patients who developed IRP, early NAI treatment versus later reduced the likelihood of mortality and needing ventilatory support.