Epidemiology, Evolution, and Long‐Term Survival of Alcoholic Cirrhosis Patients Submitted to Liver Transplantation in Southeastern Spain. (25th March 2016)

• Record Type: Journal Article
• Authors: Legaz, Isabel; Navarro‐Noguera, Elena; Bolarín, Jose M.; García‐Alonso, Ana M.; Luna Maldonado, Aurelio; Mrowiec, Anna; Campillo, Jose A.; Gimeno, Lourdes; Moya‐Quiles, Rosa; Álvarez‐López, Maria del Rocio; Minguela Puras, Alfredo; Miras, Manuel; Sánchez‐Bueno, Francisco; Muro, Manuel
• Is Part Of: Alcoholism. Volume 40:Number 4(2016)
• Page Start: 794
• Page End: 805
• Publication Date: 2016-03-25
• Subjects: Alcohol -- Alcoholic Cirrhosis -- Liver Transplant -- Survival -- Model for End‐Stage Liver Disease -- Child‐Pugh -- Liver Rejection; Alcoholism -- Periodicals; Alcoholism -- Periodicals; Alcoolisme; Electronic journals; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.861005
• DOI: 10.1111/acer.13013
• Languages: English
• ISSNs: 0145-6008

Abstract

Abstract : Background: Alcoholic cirrhosis (AC) is a common cause of death among individuals abusing alcohol. In the last resort, liver transplantation (LT) is considered the only solution to save the patient's life, generating socioeconomic and public health problems. Clinical and sociodemographic characteristics, rejection frequency, and short‐ and long‐term graft survival are not well known in end‐term AC patients undergoing LT. The aim was to determine the sociodemographic and clinical characteristics, their incidence in LT, main pre‐ and posttransplant complications, and short‐ and long‐term post‐transplant graft survival in AC patients in southeastern Spain. Methods: The medical records of 1, 026 patients who underwent LT over the last 23 years were retrospectively reviewed, and demographic data and posttransplant survivals were analyzed and compared. Biochemical characteristics, major pre‐ and posttransplant complications and short‐ and long‐term survivals were analyzed in a total of 398 male patients with AC undergoing LT. Results: AC and viral cirrhosis are the main indications for LT in our study. Mostly represented in our study are AC men without associated viral infections with a mean age of 53.06 years. Main pretransplant complications in AC patients are ascites (78.3%) and encephalopathy (43.5%), while acute graft rejection is the most common liver posttransplant complication (26.6%), nevertheless with low graft loss frequency (1.1%). AC and autoimmune cirrhosis show the best posttransplant survival in both the short and long term. Patients with AC included on the waiting list for LT were Child‐Pugh class B (52.1%) and Model for End‐Stage Liver Disease score of 10 to 19 (71.2%). The highest percentage of AC patient survival was observed at 1 year posttransplant (81.2%) and progressively decreased over time up to 10 years posttransplant (69.6%). Pretransplant complications such as ascites and encephalopathy did not have an influence on the percentage of posttransplant survivals, although better survival rates were observed in nonviral AC patients. Conclusions: AC without viral infections is the main indication for LT in southeastern Spain although its frequency has decreased in last decade. AC is a good indication for LT for its high survival rate and few posttransplant complications. Despite having a high percentage of pretransplant complications (ascites and encephalopathy) but does not appear to influence survivals being observed posttransplant survival rates above those expected. Conversely, viral infections in the patient with AC decrease patient survivals. The main future goals are design new strategies to detect, treat, and reduce AC frequency in our population and know alcoholic recidivism rate posttransplant in our population. Abstract : This figure shows Kaplan–Meier patient's survival curves according to the main indications for liver transplant in south‐eastern Spain in the short‐ and long‐term over 10 years. Ac omparative table showing statistically significant differences between the survival of alcoholic cirrhosis patients (with and without associated viral infections) and other liver transplant indications is also shown: total number of patients included in each group considered; NS, not significant.