Synthesis, Dissociation Constants, and Antimicrobial Activity of Novel 2, 3‐Disubstituted‐1, 3‐thiazolidin‐4‐one Derivatives. (7th April 2015)

• Record Type: Journal Article
• Authors: Popiołek, Łukasz; Stefańska, Joanna; Kiełczykowska, Małgorzata; Musik, Irena; Biernasiuk, Anna; Malm, Anna; Wujec, Monika
• Is Part Of: Journal of heterocyclic chemistry. Volume 53:Number 2(2016:Mar.)
• Page Start: 393
• Page End: 402
• Publication Date: 2015-04-07
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.2418
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract : In this article, a new series of 2, 3‐disubstituted‐1, 3‐thiazolidin‐4‐one derivatives have been designed, synthesized, and evaluated asantimicrobial agents . New compounds were prepared by thecyclization reaction of N ‐substituted carboxylic acid hydrazide derivatives with mercaptoacetic acid. The structures of the obtained compounds were confirmed by means of IR, 1 H NMR, and 13 C NMR spectra. The dissociation constants were determined using spectrophotometric method. All synthesized compounds were tested for their in vitro antibacterial and antifungal activities using the broth microdilution method. Abstract :