An easy and effective method for synthesis and radiolabelling of risedronate as a model for bone imaging. (9th March 2016)

• Record Type: Journal Article
• Authors: Motaleb, M. A.; Adli, A. S. A.; El‐Tawoosy, M.; Sanad, M. H.; AbdAllah, M.
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 59:Number 4(2016)
• Page Start: 157
• Page End: 163
• Publication Date: 2016-03-09
• Subjects: Bisphosphonate -- 99mTc -- Synthesis -- Risedronate -- Imaging -- Bone; Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3384
• Languages: English
• ISSNs: 0362-4803

Abstract

Abstract : This study aimed to provide an easy method for synthesis of 1‐hydroxy‐2‐(3‐pyridyl) ethylidene bisphosphonic acid monosodium (sod. risedronate) with a high yield of 71%. The synthesized risedronate was labeled with technetium‐99 m using two different reducing agents (SnCl2 .2H2 O and NaBH4 ) where NaBH4 gave stable complex and higher radiochemical yield more than SnCl2 .2H2 O. The results showed that, the radiochemical purity of 99m Tc(NaBH4 )‐risedronate was 99.2 ± 0.6% and its stability was up to 6 h. Biodistribution study showed high uptake and long retention of 99m Tc(NaBH4 )‐risedronate in bone starting from 15 min (29 ± 2.5% ID/organ) up to 4 h (35.1 ± 3.2 ID/organ) post injection. This research could introduce an easy and effective method for synthesis and labeling of risedrionate and affording a good tracer for bone imaging. Abstract : This study aimed to provide an easy method for synthesis of 1‐hydroxy‐2‐(3‐pyridyl) ethylidene bisphosphonic acid monosodium (sod. risedronate) with a high yield of 71%. The synthesized risedronate was labeled with 99m Tc using two different reducing agents (SnCl2 .2H2 O and NaBH4 ), where NaBH4 gave stable complex and higher radiochemical yield than did SnCl2 .2H2 O. Biodistribution study showed high uptake and long retention of 99m Tc(NaBH4 )‐risedronate in bone starting from 15 min (29±% ID/organ) to 6 h (35 ID/organ) post injection.