Epithelial ovarian cancer subtypes attributable to smoking in the Norwegian Women and Cancer Study, 2012. (14th January 2016)

• Record Type: Journal Article
• Authors: Licaj, Idlir; Lukic, Marko; Jareid, Mie; Lund, Eiliv; Braaten, Tonje; Gram, Inger Torhild
• Is Part Of: Cancer medicine. Volume 5:Number 4(2016:Apr.)
• Page Start: 720
• Page End: 727
• Publication Date: 2016-01-14
• Subjects: Epithelial ovarian cancer -- cohort study -- histological subtypes -- invasiveness -- population attributable fraction -- smoking; 616.994005
• DOI: 10.1002/cam4.590
• Languages: English
• ISSNs: 2045-7634

Abstract

Abstract: Among European women, ovarian cancer is the fifth most common cancer. Smoking is an established risk factor for mucinous tumors. We estimated the impact of smoking in Norwegian women using population attributable fractions (PAFs) of epithelial ovarian cancer (EOC), by invasiveness and by histological subtypes in the Norwegian Women and Cancer Study with an average of 13.2 years of follow‐up. During >2 million person‐years, a total of 915 incident EOC cases, of which 667 (73%) invasive and 248 (27%) borderline, were identified among 154, 234 women aged 34–70 years at enrolment. Compared with never smokers, current smokers had a nonstatistically significant increased risk of mucinous tumors (hazard ratio [HR] = 1.67 [95% confidence interval, (CI), 0.96–2.96]) and more than twice statistically significant risk of borderline mucinous tumors (HR = 2.17 [95% CI, 1.06–4.45]). The corresponding PAF estimates were 16.5% for mucinous and 25% for borderline mucinous. We found that among middle‐aged women, one in six mucinous tumors and one in four borderline mucinous tumors could have been prevented if women did not smoke. Abstract : Using a nationally representative cohort designed study, we calculated for the first time the fraction of epithelial ovarian cancers subtypes that are attributable to smoking in a population. This study found that among middle‐aged women, one in four of borderline mucinous tumors are attributable to cigarette smoking.