TREM2 rare variant p.R47H is not associated with Parkinson's disease. (February 2016)

• Record Type: Journal Article
• Authors: Mengel, David; Thelen, Mathias; Balzer-Geldsetzer, Monika; Söling, Charlotte; Bach, Jan-Philipp; Schaeffer, Eva; Herold, Christine; Becker, Tim; Liepelt, Inga; Becker, Julian; Riedel-Heller, Steffi; Scherer, Martin; Jessen, Frank; Maier, Wolfgang; Dodel, Richard; Ramirez, Alfredo
• Is Part Of: Parkinsonism & related disorders. Volume 23(2016)
• Page Start: 109
• Page End: 111
• Publication Date: 2016-02
• Subjects: Parkinson's disease -- Dementia -- Non-motor symptoms -- TREM2 -- Association; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2015.11.026
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Variant p.R47H of triggering receptor expressed on myeloid cells 2 ( TREM2) has been associated with Parkinson's disease (PD). We screened this TREM2 -variant in 821 PD patients including 261 demented PD patients (PDD) and in healthy controls (n = 919). Neither the entire PD nor the small PDD sample was associated with p.R47H.