A Mild TEMPO‐Catalyzed Aerobic Oxidative Conversion of Aldehydes into Nitriles. Issue 7 (17th March 2016)

• Record Type: Journal Article
• Authors: Fang, Chaojie; Li, Meichao; Hu, Xinquan; Mo, Weimin; Hu, Baoxiang; Sun, Nan; Jin, Liqun; Shen, Zhenlu
• Is Part Of: Advanced synthesis & catalysis. Volume 358:Issue 7(2016)
• Page Start: 1157
• Page End: 1163
• Publication Date: 2016-03-17
• Subjects: aldehydes -- hexamethyldisilazane (HMDS) -- nitriles -- oxidation -- oxygen -- 2, 2, 6, 6‐tetramethylpiperidine 1‐oxyl (TEMPO); Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201501130
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: An efficient method to prepare nitriles from aldehydes using hexamethyldisilazane (HMDS) as the nitrogen source has been developed. The reactions were performed with 2, 2, 6, 6‐tetramethylpiperidine l‐oxyl (TEMPO) as the catalyst, NaNO2 or TBN as the co‐catalyst, and molecular oxygen as the terminal oxidant under mild conditions. A variety of aromatic, heteroaromatic, aliphatic and allylic aldehydes could be converted into their corresponding nitriles in good to excellent yields. Abstract :