Association between premature ovarian failure, polymorphisms in MTHFR and MTRR genes and serum homocysteine concentration. Issue 4 (April 2016)

• Record Type: Journal Article
• Authors: Hou, Ningning; Chen, Songchang; Chen, Feng; Jiang, Minmin; Zhang, Junyu; Yang, Yanmei; Zhu, Bo; Bai, Xiaoxia; Hu, Yuting; Huang, Hefeng; Xu, Chenming
• Is Part Of: Reproductive biomedicine online. Volume 32:Issue 4(2016)
• Page Start: 407
• Page End: 413
• Publication Date: 2016-04
• Subjects: gene polymorphism -- homocysteine -- MTHFR -- MTRR -- premature ovarian failure; Human reproductive technology -- Periodicals; Human embryo -- Periodicals; Reproduction -- Periodicals; 616.692
• DOI: 10.1016/j.rbmo.2016.01.009
• Languages: English
• ISSNs: 1472-6483

Abstract

Abstract: This study investigated the association between premature ovarian failure (POF), MTHFR C677T/A1298C and MTRR A66G genotypes and serum homocysteine (Hcy) concentration. A prospective study was conducted in Chinese women, which included POF patients ( n = 180) and controls ( n = 195). Peripheral blood samples were used to determine MTHFR C677T/A1298C and MTRR A66G genotypes, and serum Hcy and sex hormone concentrations. Results showed that serum Hcy concentrations of POF patients were significantly higher than those of controls ( P < 0.0001). In POF patients, serum Hcy concentrations were significantly correlated with oestradiol and FSH concentrations ( r = −0.174, P = 0.037 and r = +0.238, P = 0.006, respectively). There were no significant differences in the distributions of MTHFR C677T/A1298C or MTRR A66G genotypes between the two groups. However, these genetic variants influenced serum Hcy concentrations in POF patients, especially for MTRR 66 AA/AG/GG genotypes, which were significantly correlated with the patients' Hcy concentrations ( τ = 0.166, P = 0.033). These results suggest that serum Hcy concentrations in Chinese POF patients are increased and correlated with serum oestradiol/FSH concentrations. In conclusion, MTHFR C667T/A1298C and MTRR A66G genotypes are not associated with POF development, but they affect the patients' serum Hcy concentrations.