The role of feeding rhythm, adrenal hormones and neuronal inputs in synchronizing daily clock gene rhythms in the liver. (15th February 2016)

• Record Type: Journal Article
• Authors: Su, Yan; Cailotto, Cathy; Foppen, Ewout; Jansen, Remi; Zhang, Zhi; Buijs, Ruud; Fliers, Eric; Kalsbeek, Andries
• Is Part Of: Molecular and cellular endocrinology. Volume 422(2016)
• Page Start: 125
• Page End: 131
• Publication Date: 2016-02-15
• Subjects: Circadian -- Feeding -- Adrenalectomy -- Denervation -- Clock genes -- Liver; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2015.12.011
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: The master clock in the hypothalamic suprachiasmatic nucleus (SCN) is assumed to distribute rhythmic information to the periphery via neural, humoral and/or behavioral connections. Until now, feeding, corticosterone and neural inputs are considered important signals for synchronizing daily rhythms in the liver. In this study, we investigated the necessity of neural inputs as well as of the feeding and adrenal hormone rhythms for maintaining daily hepatic clock gene rhythms. Clock genes kept their daily rhythm when only one of these three signals was disrupted, or when we disrupted hepatic neuronal inputs together with the adrenal hormone rhythm or with the daily feeding rhythm. However, all clock genes studied lost their daily expression rhythm after simultaneous disruption of the feeding and adrenal hormone rhythm. These data indicate that either a daily rhythm of feeding or adrenal hormones should be present to synchronize clock gene rhythms in the liver with the SCN. Graphical abstract: Highlights: Rhythmic feeding or adrenal hormones are not indispensable for synchronization. Neuronal signals are not very important to synchronize daily rhythms in liver. Absence of rhythmic feeding and adrenal hormones deletes hepatic clock gene rhythm.