Challenges and outcome of surgery for bowel obstruction in women with gynaecologic cancer. (March 2016)

• Record Type: Journal Article
• Authors: Furnes, Bjorg; Svensen, Rune; Helland, Harald; Ovrebo, Kjell
• Is Part Of: International journal of surgery. Volume 27(2016)
• Page Start: 158
• Page End: 164
• Publication Date: 2016-03
• Subjects: Intestinal obstruction -- Gynaecologic neoplasms -- Palliative treatment -- Palliative surgery -- Surgery -- Hospital mortality -- Postoperative complications; Surgery -- Periodicals; Surgical Procedures, Operative -- Periodicals; 617.005
• DOI: 10.1016/j.ijsu.2016.02.002
• Languages: English
• ISSNs: 1743-9191

Abstract

Abstract: Introduction: Bowel obstruction is associated with a reduction in quality of life and survival among cancer patients, and the entity is traditionally treated by general surgeons without dedication to the different malignancies that cause bowel obstruction or to palliation. This study aims to identify and improve outcome of bowel obstruction in women with a history of a gynaecologic cancer. Methods: Women operated for bowel obstruction were screened for a history of gynaecologic cancer and their records were reviewed. Results: Bowel obstruction followed cancer treatment by a median of 18.4 months (range 2.3–277) in 59 women. A malignant cause was identified in 53% and recurrence of cancer in 61%. The cause of malignant bowel obstruction was peritoneal carcinomatosis (19%), obstructing tumour and carcinomatosis (31%) and solitary tumour (3%). Ovarian cancer (OR: 6.29, 95% CI 1.95–20.21), residual tumour during initial surgery (R2-stage) (OR: 18.7, 96% CI: 4.35–80.46) and chemotherapy (OR: 7.19, 95% CI: 2.28–22.67) were all associated with malignant bowel obstruction. Surgery solved 84% of malignant bowel obstructions, but median survival was brief (2.5 months, 95% CI: 1.4–3.6) when compared to benign bowel obstruction (95.3 months, 64.7–125.9) (p < 0.001). Readmission for bowel obstruction occurred after a median of 4.3 months (95% CI: 3.1–5.5) in surviving patients with malignant bowel obstruction and after a median of 84.5 months (95% CI: 73.6–95.3) with adhesive obstruction (p < 0.001). Conclusions: Increased awareness of the aetiology to bowel obstruction may improve treatment strategy in these women. Women with malignant bowel obstruction should be carefully identified and differentiated in order to improve quality of life rather than pursuing emergency surgical procedures. Highlights: Patient with former gynaecologic cancer and bowel obstruction need careful differentiation. Recurrent gynaecologic cancer is associated with malignant bowel obstruction. Surgery solve malignant bowel obstruction in gynaecologic cancer. Complication rates are high and survival short. Observation may be an option in patients with malignant bowel obstruction.