Evaluation of breast cancer risk associated with tea consumption by menopausal and estrogen receptor status among Chinese women in Hong Kong. (February 2016)

• Record Type: Journal Article
• Authors: Li, Mengjie; Tse, Lap Ah; Chan, Wing-cheong; Kwok, Chi-hei; Leung, Siu-lan; Wu, Cherry; Yu, Wai-cho; Yu, Ignatius Tak-sun; Yu, Chloe Hui-Tung; Wang, Feng; Sung, Hyuna; Yang, Xiaohong R.
• Is Part Of: Cancer epidemiology. Volume 40(2016:Feb.)
• Page Start: 73
• Page End: 78
• Publication Date: 2016-02
• Subjects: Tea consumption -- Breast cancer -- Menopausal status -- Estrogen receptor status; Cancer -- Epidemiology -- Periodicals; Cancer -- Prevention -- Periodicals; Cancer -- Diagnosis -- Periodicals; Carcinogenesis -- Periodicals; 616.994005
• DOI: 10.1016/j.canep.2015.11.013
• Languages: English
• ISSNs: 1877-7821

Abstract

Highlights: Tea or green tea drinking was not associated with overall breast cancer risk. Tea consumption may have dual effect on breast cancer risk by menopausal status. The effect of tea on breast cancer risk may also vary by onset of tea drinking. Tea-breast cancer association may be modified by hormone receptor expression. Abstract: Purpose: Experimental studies implicate tea and tea polyphenols may be preventive against breast cancer, but evidence from epidemiological studies has been inconsistent. We conducted a hospital-based case–control study to evaluate the role of tea especially green tea in breast cancer etiology. Methods: We consecutively recruited 756 incident breast cancer cases and 789 hospital controls who had completed information on tea consumption. We calculated odds ratios (ORs) for tea consumption using unconditional multivariable logistic regression. We further conducted stratified analyses to assess whether the effect of tea consumption varied by menopausal status and estrogen receptor (ER). Results: Overall, 439 (58.1%) breast cancer cases and 434 (55.0%) controls reported habits of regular tea drinking, showing an adjusted OR of 1.01 (95%CI: 0.78–1.31) and 1.20 (95%CI: 0.80–1.78) for any tea and green tea drinking, respectively. Regular tea drinking was significantly associated with a lower risk for breast cancer in pre-menopausal women (OR = 0.62, 95%CI: 0.40–0.97) but an increased risk in post-menopausal women (OR = 1.40, 95%CI: 1.00–1.96). The positive association among postmenopausal women was strongest among ER-negative green tea drinkers (OR = 2.99, 95% CI: 1.26–7.11). Conclusions: Tea or green tea drinking was not associated with overall breast cancer risk, which may be masked by the differential effect in pre- and post-menopausal women.