Emotion dysregulation and amygdala dopamine D2-type receptor availability in methamphetamine users. (1st April 2016)

• Record Type: Journal Article
• Authors: Okita, Kyoji; Ghahremani, Dara G.; Payer, Doris E.; Robertson, Chelsea L.; Dean, Andy C.; Mandelkern, Mark A.; London, Edythe D.
• Is Part Of: Drug and alcohol dependence. Volume 161(2016)
• Page Start: 163
• Page End: 170
• Publication Date: 2016-04-01
• Subjects: Methamphetamine -- Amygdala -- Emotion dysregulation -- Dopamine -- [18F]Fallypride -- PET; Drug abuse -- Periodicals; Alcoholism -- Periodicals; 616.86
• DOI: 10.1016/j.drugalcdep.2016.01.029
• Languages: English
• ISSNs: 0376-8716

Abstract

Highlights: Methamphetamine users versus healthy controls show impaired emotion regulation. Emotion-dysregulation is related to dopamine receptor availability in amygdala. That relationship is found in both of methamphetamine users and healthy controls. Abstract: Background: Individuals who use methamphetamine chronically exhibit emotional and dopaminergic neurochemical deficits. Although the amygdala has an important role in emotion processing and receives dopaminergic innervation, little is known about how dopamine transmission in this region contributes to emotion regulation. This investigation aimed to evaluate emotion regulation in subjects who met DSM-IV criteria for methamphetamine dependence, and to test for a relationship between self-reports of difficulty in emotion regulation and D2-type dopamine receptor availability in the amygdala. Method: Ninety-four methamphetamine-using and 102 healthy-control subjects completed the Difficulties in Emotion Regulation Scale (DERS); 33 of those who used methamphetamine completed the Addiction Severity Index (ASI). A subset of 27 methamphetamine-group and 20 control-group subjects completed positron emission tomography with [ 18 F]fallypride to assay amygdala D2-type dopamine receptor availability, measured as binding potential (BPND ). Results: The methamphetamine group scored higher than the control group on the DERS total score ( p < 0.001), with DERS total score positively correlated with the Drug Composite Score on the ASI ( p = 0.02) in the methamphetamine group. The DERS total score was positively correlated with amygdala BPND in both groups and the combined group of participants (combined: r = 0.331, p = 0.02), and the groups did not differ in this relationship. Conclusion: These findings highlight problems with emotion regulation linked to methamphetamine use, possibly contributing to personal and interpersonal behavioral problems. They also suggest that D2-type dopamine receptors in the amygdala contribute to emotion regulation in both healthy and methamphetamine-using subjects.