Longitudinal changes in adiponectin multimer levels in preterm infants. (April 2016)

• Record Type: Journal Article
• Authors: Nakano, Yuya; Itabashi, Kazuo; Dobashi, Kazushige; Mizuno, Katsumi
• Is Part Of: Early human development. Volume 95(2016)
• Page Start: 29
• Page End: 33
• Publication Date: 2016-04
• Subjects: Adiponectin -- Preterm infants -- Infancy -- Longitudinal changes; Fetus -- Periodicals; Neonatology -- Periodicals; Prenatal influences -- Periodicals; 612.65
• DOI: 10.1016/j.earlhumdev.2016.01.022
• Languages: English
• ISSNs: 0378-3782

Abstract

Abstract: Background: Preterm infants have altered adiponectin levels at term-equivalent age and have a higher risk of developing components of the metabolic syndrome in later life than term infants. Aims: To investigate the longitudinal changes in adiponectin levels in preterm infants and to compare the levels between term and preterm infants. Study design: A cohort study. Subjects: The study subjects were 43 term infants and 42 preterm infants born at ≤ 34-week gestation. Outcome measures: Serum levels of total adiponectin (T-Ad) and high-molecular-weight adiponectin (HMW-Ad) were measured in 42 preterm infants at term-, 6 month-, and 12 month-equivalent ages. Moreover, the levels in 43 term infants investigated previously were reviewed. Results: In preterm infants, T-Ad and HMW-Ad levels at the 12 month-equivalent age were lower than at the term- and 6 month-equivalent ages (all values p < 0.001), which was consistent with previous results in term infants. The difference in ratios of HMW-Ad to T-Ad between term and preterm infants continued at the 6 month-equivalent age but disappeared at the 12 month-equivalent age. Multiple regression analyses revealed that HMW-Ad levels at term-equivalent age were only a significant determinant of the changes in HMW-Ad between the term- and 12 month-equivalent ages in preterm infants (p < 0.001). Conclusions: The HMW-Ad levels decline till the 12 month-equivalent age in both term and preterm infants. The changes in HMW-Ad level during infancy might be determined at least to a certain degree up to term-equivalent age in preterm infants.