A novel benzofurazan-cyclam conjugate and its Cu(II) complex: Synthesis, characterization and in vitro cytotoxicity and antimicrobial activity. (June 2016)

• Record Type: Journal Article
• Authors: Grabchev, Ivo; Yordanova, Stanislava; Vasileva-Tonkova, Evgenia; Cangiotti, Michela; Fattori, Alberto; Alexandrova, Radostina; Stoyanov, Stanimir; Ottaviani, Maria Francesca
• Is Part Of: Dyes and pigments. Volume 129(2016)
• Page Start: 71
• Page End: 79
• Publication Date: 2016-06
• Subjects: Benzofurazan -- Cyclam -- Copper complex -- Antimicrobial -- Cytotoxicity -- EPR -- Photophysical; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2016.02.013
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: A novel benzofurazan-cyclam conjugate and its Cu(II) complex have been synthesized and characterized. The photophysical properties have been investigated in organic solvents with different polarity. It has been found that the new compound is solvatochromic in nature. The biological activity of the resulting compounds was investigated to evaluate the effectiveness of these molecules as potential antimicrobial agents. The copper free ligand showed antibacterial and antifungal activity which increased after the formation of a copper complex. In contrast the cytotox1icity against human Hela cervical carcinoma and human MDA-MB-231 breast cancer cells is more pronounced at the free ligand. The results suggest that the new compounds are promising for application in biomedicine in the design of new effective preparations. Graphical abstract: Highlights: The synthesis and characterization of new benzofurazan-cyclam conjugate is presented. The synthesis of a new copper complex has been described and characterized. EPR analysis of complex is presented. New compounds possessed antimicrobial and cytotoxic activity.