Energy metabolism in the acquisition and maintenance of stemness. (April 2016)

• Record Type: Journal Article
• Authors: Folmes, Clifford D.L.; Terzic, Andre
• Is Part Of: Seminars in cell & developmental biology. Volume 52(2016)
• Page Start: 68
• Page End: 75
• Publication Date: 2016-04
• Subjects: Glycolysis -- Oxidative metabolism -- Nuclear reprograming -- Induced pluripotent stem cells -- Embryonic stem cells -- Hematopoietic stem cells -- Mitochondria -- Metabolic remodeling; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2016.02.010
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: Energy metabolism is traditionally considered a reactive homeostatic system addressing stage-specific cellular energy needs. There is however growing appreciation of metabolic pathways in the active control of vital cell functions. Case in point, the stem cell lifecycle – from maintenance and acquisition of stemness to lineage commitment and specification – is increasingly recognized as a metabolism-dependent process. Indeed, metabolic reprogramming is an early contributor to the orchestrated departure from or reacquisition of stemness. Recent advances in metabolomics have helped decipher the identity and dynamics of metabolic fluxes implicated in fueling cell fate choices by regulating the epigenetic and transcriptional identity of a cell. Metabolic cues, internal and/or external to the stem cell niche, facilitate progenitor pool restitution, long-term tissue renewal or ensure adoption of cytoprotective behavior. Convergence of energy metabolism with stem cell fate regulation opens a new avenue in understanding primordial developmental biology principles with future applications in regenerative medicine practice.