A new childhood asthma phenotype: obese with early menarche. (March 2016)

• Record Type: Journal Article
• Authors: Castro-Rodriguez, Jose A.
• Is Part Of: Paediatric respiratory reviews. Volume 18(2016)
• Page Start: 85
• Page End: 89
• Publication Date: 2016-03
• Subjects: aOR adjusted odds ratio -- aHR adjusted hazard ratio -- BHR bronchial hyperresponsiveness -- BMI body mass index -- CI confidence interval -- FEV1 forced expiratory volume in the first second -- FVC forced vital capacity -- GWA genome-wide association -- PR prevalence ratio -- SNP single nucleotide polymorphism.; Asthma phenotype -- Childhood -- Obesity -- Early menarche -- Epidemiology -- Genetics; Pediatric respiratory diseases -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory Therapy -- Periodicals; Child -- Periodicals; Appareil respiratoire -- Infections, chez l'enfant -- Périodiques; Appareil respiratoire -- Maladies, chez l'enfant -- Périodiques; 618.922
• DOI: 10.1016/j.prrv.2015.10.006
• Languages: English
• ISSNs: 1526-0542

Abstract

Summary: Three concomitant phenomena occur in the later years of childhood: increases in the incidence of asthma, obesity and early menarche. This article is an overview of the current epidemiologic, basic, genetic and epigenetic evidence about this relationship. As a consequence we propose that obese girls who have an early menarche (≤ 11 years of age) constitute a new asthma phenotype in childhood. Future studies need to be carried out in order to find the best control and treatment of this new asthma phenotype.