Disrupted Intrinsic Connectivity among Default, Dorsal Attention, and Frontoparietal Control Networks in Individuals with Chronic Traumatic Brain Injury*. (18th February 2016)

• Record Type: Journal Article
• Authors: Han, Kihwan; Chapman, Sandra B.; Krawczyk, Daniel C.
• Editors: Barch, Deanna M.; Verfaellie, Mieke; Rao, Stephen M.
• Is Part Of: Journal of the International Neuropsychological Society. Volume 22:Number 2(2016)
• Page Start: 263
• Page End: 279
• Publication Date: 2016-02-18
• Subjects: TBI, -- Functional connectivity, -- fMRI, -- Default network, -- Attention network, -- Fronto-parietal control network, -- Graph theory, -- Goal-directed cognition; Neuropsychology -- Periodicals; 616.8
• DOI: 10.1017/S1355617715001393
• Languages: English
• ISSNs: 1355-6177

Abstract

Abstract: Objectives: Individuals with chronic traumatic brain injury (TBI) often show detrimental deficits in higher order cognitive functions requiring coordination of multiple brain networks. Although assessing TBI-related deficits in higher order cognition in the context of network dysfunction is promising, few studies have systematically investigated altered interactions among multiple networks in chronic TBI.Method: We characterized disrupted resting-state functional connectivity of the default mode network (DMN), dorsal attention network (DAN), and frontoparietal control network (FPCN) whose interactions are required for internally and externally focused goal-directed cognition in chronic TBI. Specifically, we compared the network interactions of 40 chronic TBI individuals (8 years post-injury on average) with those of 17 healthy individuals matched for gender, age, and years of education.Results: The network-based statistic (NBS) on DMN-DAN-FPCN connectivity of these groups revealed statistically significant ( p NBS <.05; | Z| >2.58) reductions in within-DMN, within-FPCN, DMN-DAN, and DMN-FPCN connectivity of the TBI group over healthy controls. Importantly, such disruptions occurred prominently in between-network connectivity. Subsequent analyses further exhibited the disrupted connectivity patterns of the chronic TBI group occurring preferentially in long-range and inter-hemispheric connectivity of DMN-DAN-FPCN. Most importantly, graph-theoretic analysis demonstrated relative reductions in global, local and cost efficiency ( p <.05) as a consequence of the network disruption patterns in the TBI group.Conclusion: Our findings suggest that assessing multiple networks-of-interest simultaneously will allow us to better understand deficits in goal-directed cognition and other higher order cognitive phenomena in chronic TBI. Future research will be needed to better understand the behavioral consequences related to these network disruptions. ( JINS, 2016, 22, 263–279)