Common and Rare Genetic Variants Associated With Alzheimer's Disease. Issue 7 (17th December 2015)

• Record Type: Journal Article
• Authors: Marei, Hany E.; Althani, Asmaa; Suhonen, Jaana; El Zowalaty, Mohamed E.; Albanna, Mohammad A.; Cenciarelli, Carlo; Wang, Tengfei; Caceci, Thomas
• Is Part Of: Journal of cellular physiology. Volume 231:Issue 7(2016:Jul.)
• Page Start: 1432
• Page End: 1437
• Publication Date: 2015-12-17
• Subjects: Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.25225
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract : Alzheimer's disease (AD) is one of the most devastating disorders. Despite the continuing increase of its incidence among aging populations, no effective cure has been developed mainly due to difficulties in early diagnosis of the disease before damaging of the brain, and the failure to explore its complex underlying molecular mechanisms. Recent technological advances in genome‐wide association studies (GWAS) and high throughput next generation whole genome, and exome sequencing had deciphered many of AD‐related loci, and discovered single nucleotide polymorphisms (SNPs) that are associated with altered AD molecular pathways. Highlighting altered molecular pathways linked to AD pathogenesis is crucial to identify novel diagnostic and therapeutic AD targets. J. Cell. Physiol. 231: 1432–1437, 2016. © 2015 Wiley Periodicals, Inc.