Deciphering the in vitro homo and hetero oligomerization characteristics of CXCL1/CXCL2 chemokines. Issue 34 (17th March 2016)

• Record Type: Journal Article
• Authors: Gulati, Khushboo; Poluri, Krishna Mohan
• Is Part Of: RSC advances. Volume 6:Issue 34(2016)
• Page Start: 28213
• Page End: 28218
• Publication Date: 2016-03-17
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra01884j
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Murine GRO chemokines CXCL1(mKC)/CXCL2(MIP2) forms heterodimers and thus adding another layer of regulatory mechanism for leukocyte trafficking during infection/inflammation. Abstract : Chemokines share the fundamental property of oligomerization and regulate leukocyte migration via interacting with glycosaminoglycans and G-protein coupled receptors. Our studies on murine neutrophil activating chemokines CXCL1(mKC)/CXCL2(MIP2) deciphered their differential homo oligomerization potentials and heterodimer forming capabilities, thus adding another layer of regulatory mechanism for leukocyte trafficking during infection/inflammation.