Inside Cover: Aliphatic Halogenase Enables Late‐Stage C−H Functionalization: Selective Synthesis of a Brominated Fischerindole Alkaloid with Enhanced Antibacterial Activity (ChemBioChem 6/2016). (15th March 2016)

• Record Type: Journal Article
• Authors: Zhu, Qin; Hillwig, Matthew L.; Doi, Yohei; Liu, Xinyu
• Is Part Of: Chembiochem. Volume 17:Number 6(2016)
• Page Start: 442
• Page End: 442
• Publication Date: 2016-03-15
• Subjects: alkaloid biogenesis -- antibiotics -- C−H activation -- halogenases -- non-heme iron enzymes; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201600114
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract : The inside cover picture shows that a newly discovered stand‐alone non‐heme iron halogenase WelO5 from cyanobacterium Hapalosiphon welwitschii (background image) can selectively modify antibiotic molecule 12‐ epi ‐fischerindole U (left) by late‐stage oxidative functionalization of an aliphatic C−H group with bromine to give 13 R ‐bromo‐12‐ epi ‐fischerindole U (right) with enhanced antibacterial activity against human pathogen Staphylococcus aureus (bottom). More information can be found in the communication by X. Liu et al. onpage 466 in Issue 6, 2016 (DOI:10.1002/cbic.201500674 ).