Transition-metal free alkylarylation of acrylamides initiated by radical C–C bond cleavage of the tertiary cycloalkanols. Issue 32 (14th March 2016)

• Record Type: Journal Article
• Authors: Guo, Li-Na; Deng, Zhi-Qiang; Wu, Yong; Hu, Jie
• Is Part Of: RSC advances. Volume 6:Issue 32(2016)
• Page Start: 27000
• Page End: 27003
• Publication Date: 2016-03-14
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra03431d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : An efficient Na2 S2 O8 -promoted radical cyclization reaction of acrylamides with the tertiary cycloalkanols has been developed. This one pot procedure involves a tandem C–C bond cleavage and two C–C bonds formation process. Abstract : An efficient Na2 S2 O8 -promoted radical cyclization reaction of acrylamides with the tertiary cycloalkanols has been developed. This one pot procedure involves a tandem C–C bond cleavage and two C–C bonds formation process. The key advantages of this protocol are its transition-metal free, its operational simplicity and its excellent functional group tolerance, thus allowing a facile access to oxindoles containing a carbonyl group.