Study and application of noncatalyzed photoinduced conjugation of azides and cycloocta-1, 2, 3-selenadiazoles. Issue 26 (9th March 2016)

• Record Type: Journal Article
• Authors: Jedináková, P.; Šebej, P.; Slanina, T.; Klán, P.; Hlaváč, J.
• Is Part Of: Chemical communications. Volume 52:Issue 26(2016)
• Page Start: 4792
• Page End: 4795
• Publication Date: 2016-03-09
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc01789d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The non-catalyzed cycloaddition of eight structurally different azides with cyclooctyne generated in situ by the photolysis of cycloocta-1, 2, 3-selenadiazole gives 1, 2, 3-triazole derivatives as the main products. Abstract : The non-catalyzed cycloaddition of eight structurally different azides with cyclooctyne generated in situ by the photolysis of cycloocta-1, 2, 3-selenadiazole gives 1, 2, 3-triazole derivatives as the main products. The application of this reaction was demonstrated by the photoconjugation reaction of cycloocta-1, 2, 3-selenadiazole with an avidin-modified biotin complex to introduce a new strategy in the non-catalyzed synthesis of bioconjugates.