Glycopeptide antibiotic analogs for selective inactivation and two-photon imaging of vancomycin-resistant strains. Issue 25 (8th March 2016)

• Record Type: Journal Article
• Authors: Ariyasu, Shinya; Too, Pei Chui; Mu, Jing; Goh, Chi Ching; Ding, Yichen; Tnay, Ya Lin; Yeow, Edwin Kok Lee; Yang, Liang; Ng, Lai Guan; Chiba, Shunsuke; Xing, Bengang
• Is Part Of: Chemical communications. Volume 52:Issue 25(2016)
• Page Start: 4667
• Page End: 4670
• Publication Date: 2016-03-08
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc10230h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Theranostic divalent vancomycin systems exhibit selective antibacterial activity against vancomycin-resistant strains and can be applied for two-photon fluorescence imaging. Abstract : A novel theranostic divalent vancomycin analog using a planar 1, 8-diazapyrene moiety as a rigid scaffold exhibits potent and selective antibacterial activity against Gram (+) bacteria including vancomycin-resistant strains, while having minimal influence on Gram (−) bacteria and mammalian cells. Moreover, this theranostic analog can be also applied for selective two-photon fluorescence imaging of Gram (+) bacteria.