Intracranial tumour haemorrhage following intravenous thrombolysis. (April 2016)

• Record Type: Journal Article
• Authors: Diehl, Christian; Haux, Daniel; Sahm, Felix; Unterberg, Andreas W.; Beynon, Christopher
• Is Part Of: Journal of clinical neuroscience. Volume 26(2016:Apr.)
• Page Start: 145
• Page End: 146
• Publication Date: 2016-04
• Subjects: Fibrinolysis -- Haemorrhage -- Intracranial neoplasm -- Thrombolysis; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2015.08.032
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: Thrombolysis is generally considered contraindicated in patients with intracranial neoplasms. A patient developed ICH into a previously unknown meningioma after thrombolysis. Intracranial neoplasms may be the causative pathology in thrombolysis-related ICH. Abstract: Intravenous administration of thrombolytic agents is considered to be contraindicated in patients with intracranial neoplasms. However, only a single case of thrombolysis-related intracranial tumour haemorrhage has been reported to our knowledge and several studies have suggested that systemic thrombolysis can be safely carried out in these patients. Here we report a patient who developed haemorrhage into a previously unknown intracranial tumour following intravenous thrombolysis for acute myocardial ST-elevation infarction. Identification of abnormal tissue during surgical haematoma evacuation initiated histopathological examination which revealed meningioma World Health Organization Grade I. Intracranial tumours may represent the causative pathology in cases of thrombolysis-related intracranial haemorrhage and this should be considered in the treatment of these patients.