Syphilis screening practices in blood transfusion facilities in Ghana. (February 2016)

• Record Type: Journal Article
• Authors: Sarkodie, Francis; Hassall, Oliver; Owusu-Dabo, Ellis; Owusu-Ofori, Shirley; Bates, Imelda; Bygbjerg, Ib C.; Ansah, Justina Kordai; Ullum, Henrik
• Is Part Of: International journal of infectious diseases. Volume 43(2016:Feb.)
• Page Start: 90
• Page End: 94
• Publication Date: 2016-02
• Subjects: Transfusion facilities -- Standard operating procedures -- Blood donors -- Rapid diagnostic tests -- Seroprevalence; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2015.12.020
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlights: Laboratory technical heads of 122 of the total 149 transfusion facilities in Ghana were interviewed. Present syphilis screening practices in Ghana were compared with World Health Organization and National Blood Service, Ghana recommendations. It was determined whether standard operating procedures were used for syphilis screening in Ghana. Only 58 (48%) transfusion facilities tested donors for syphilis, with an estimated 3.7% seroprevalence (95% CI 3.6–3.8%). There is a low syphilis testing rate and a relatively high use of non-approved, non-validated test kits (rapid diagnostic tests, RDTs) for syphilis screening, obtained at different costs, in Ghana. Summary: Objectives: The primary objective of this study was to compare laboratory practices for screening blood donors for syphilis at blood transfusion facilities in Ghana with the recommendations of the World Health Organization and the National Blood Service, Ghana (NBSG). The prevalence of syphilis antibodies in blood donors in Ghana was also estimated. Methods: Over an 11-month period, from February 2014 to January 2015, a semi-structured questionnaire was administered to 122 laboratory technical heads out of a total of 149 transfusion facilities in Ghana. The response rate was 81.9%. Results: A total of 58 (48%) transfusion facilities tested donors for syphilis, with an estimated 3.7% seroprevalence (95% confidence interval 3.6–3.8%). A total of 62 782 out of 91 386 (68.7%) donations were tested with assays that are not recommended. The estimated syphilis seroprevalence in voluntary donations was 2.9%, compared to 4.0% in family donations ( p = 0.001). Only 6.9% of the health facilities were using standard operating procedures (SOPs). Conclusions: Despite international and national recommendations, more than half of the studied health facilities that provide blood transfusions in Ghana are not screening blood donations for syphilis. These data show a considerable mismatch between recommendations and practice, with serious consequences for blood safety and public health.