Chemical composition and hypoglycaemic effect of polyphenol extracts from Litchi chinensis seeds. (April 2016)

• Record Type: Journal Article
• Authors: Man, Shuli; Ma, Jiang; Wang, Chunxia; Li, Yu; Gao, Wenyuan; Lu, Fuping
• Is Part Of: Journal of functional foods. Volume 22(2016)
• Page Start: 313
• Page End: 324
• Publication Date: 2016-04
• Subjects: Litchi seeds -- Diabetes -- Lipid metabolism -- Inflammation -- Apoptosis; ACO Acyl-CoA oxidase -- AUC area under curve -- DGAT diacyl glycerol acyl transferase -- ELISA enzyme-linked immunosorbent assay -- FAS fatty acid synthetase -- FBG fasting blood glucose -- FSI fasting serum insulin -- HDL-C high density lipoprotein cholesterol -- HFD high fat diet -- HPLC high performance liquid chromatography -- ISI insulin sensitivity index -- IRI insulin resistance index -- LDH lactate dehydrogenase -- LDL-C low density lipoprotein cholesterol -- LSE Litchi seeds extract -- OGTT oral glucose tolerance tests -- RT-PCR reverse transcription polymerase chain reaction -- STZ streptozotocin -- T-CHO total cholesterol -- T2D type 2 diabetes -- TG total triacylglycerol -- UPLC/DAD-ESI-Q/TOF-MS Ultra-performance liquid chromatography/diode-array detection electrospray ionization quadrupole time-of-flight mass spectrometry; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2016.01.032
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: D101 macroporous was used to purify polyphenols of Litchi seeds (LSE). There are multiple catechin-rich compounds and pinocembrin glycosides in LSE. LST may be a potential agent for the prevention of early type 2 diabetes. Abstract: The hypoglycaemic effects of Litchi chinensis Sonn. seeds extract (LSE ) on type 2 diabetic (T2D ) rats and the active constituents from LSE were investigated. As a result, 21 compounds including 3, 5-dihydroxybenzoic acid, 3, 4-dihydroxybenzaldehyde, procyanidin D, cianidanol, cinnamtannin B1, procyanidin A1, scopoletin, rutin, phlorizin and epicatechin–epicatechin–catechin were identified by UPLC-Q/TOF-MS. The content of polyphenols reached 43.37 ± 2.34 g of cianidanol/100 g. After one-month treatment, LSE improved quality of life of streptozotocin (STZ )/high fat diet induced T2D rats and protected against pancreas, liver and kidney tissues damage through the improvement of glucose tolerance and insulin resistance. In addition, LSE influenced lipid metabolism and increased mRNA levels of Bax and NF-κB, thereby inhibiting apoptosis-induced hepatic damage and inflammation to protect the body against diabetic exacerbation. For the first time, this study delineated Litchi seeds' anti-diabetic prospect of treatment for type 2 diabetes.