Turmeric ethanolic extract possesses stronger inhibitory activities on colon tumour growth than curcumin – The importance of turmerones. (April 2016)

• Record Type: Journal Article
• Authors: Yue, Grace Gar-Lee; Jiang, Lei; Kwok, Hin-Fai; Lee, Julia Kin-Ming; Chan, Kar-Man; Fung, Kwok-Pui; Leung, Ping-Chung; Lau, Clara Bik-San
• Is Part Of: Journal of functional foods. Volume 22(2016)
• Page Start: 565
• Page End: 577
• Publication Date: 2016-04
• Subjects: Angiogenesis -- Colorectal cancer -- Curcuma longa -- Curcumin -- Synergism -- Turmerone; Curcumin (PubChem CID: 969516) -- Aromatic-turmerone (PubChem CID: 160512) -- α-turmerone (PubChem CID: 14632996) -- β-turmerone (PubChem CID: 196216); Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2016.02.011
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: Turmerones enhanced anti-proliferative effects of curcumin in colon cancer cells. Turmerones augmented anti-angiogenic activities of curcumin in endothelial cells. Turmeric extract exerted superior in vivo anti-tumour effects against curcumin alone. Turmeric extract might serve as potential adjuvant therapy for colorectal cancer. Abstract: The active ingredient curcuminoid (including curcumin, demethoxycurcumin and bisdemethoxycurcumin) from the Asian medicinal and culinary herb turmeric possesses anti-tumour effects, but poor oral absorption in the intestine impedes its widespread clinical application. Our previous study showed that turmerones increased the accumulation of curcumin inside colonic cells. The present study demonstrates the enhanced anti-proliferative and anti-angiogenic activities of curcumin in the presence of turmerones in human colon cancer cells and endothelial cells, respectively. Furthermore, in HT29 tumour xenograft-bearing mice fed with curcumin alone or turmeric ethanolic extract (in which the concentration of curcumin was kept the same), the tumour burden of turmeric extract-fed mice was the lowest, suggesting turmeric extract provided better anti-tumour activities than the same amount of curcumin alone did. The superior anti-tumour effects of turmeric extract, which contains curcumin, turmerones and other constituents, were verified in tumour-bearing mice, indicating the potential use of turmeric for colorectal cancer adjuvant therapy.