Influence of repetitive transcranial magnetic stimulation on tibialis anterior activity during walking in humans. (11th March 2016)

• Record Type: Journal Article
• Authors: Rambour, Mélanie; Caux-Dedeystère, Alexandre; Devanne, Hervé; Defebvre, Luc; Derambure, Philippe; Delval, Arnaud
• Is Part Of: Neuroscience letters. Volume 616(2016)
• Page Start: 49
• Page End: 56
• Publication Date: 2016-03-11
• Subjects: Repetitive transcranial magnetic stimulation -- Tibialis anterior -- Primary motor cortex -- Gait; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2016.01.027
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: We tried to modulate activity of the tibialis anterior (TA) during gait. We used repetitive transcranial magnetic stimulation on the M1 region controlling the lower limb. We did not observe any effects of rTMS in terms of TA activation during locomotion or cortical excitability. The results were similar for both healthy young adults and elderly adults. Reasons of this lack of modulation can be multiple and variable. Abstract: Objective: To determine whether or not modulation of the excitability of the M1 region controlling the lower limb (using repetitive transcranial magnetic stimulation; TMS) would change the TA's activity during gait and the effect of aging on this change. Methods: In three separate sessions, participants underwent different repetitive TMS (rTMS) protocols (sham stimulation, intermittent theta-burst stimulation (TBS) and continuous TBS) delivered over the M1 region controlling the lower limb muscles, using a focal, figure-of-eight coil. Before and after rTMS, the TA's activity was recorded using surface electrodes while participants walked at a freely chosen speed and at an imposed speed on a treadmill. Cortical excitability was assessed by characterizing input–output (IO) curves, after fitting the relationship between motor evoked potential amplitude and stimulus intensity with a Boltzmann sigmoidal equation. Results: We did not observe any effects of rTMS in terms of TA activation during locomotion, gait parameters or IO curves in either healthy young adults or elderly adults. Elderly patients presented lower excitability of cortical TA representation area. Conclusion: Modulation of TA activity by TBS was ineffective contrary to what is observed for upper limbs. Interindividual variability in the effects of rTMS on TA activation, activation of the TA before the rTMS and/or differences in the depth of the cortical representation of the TA could have influenced the results and should be taken into account for further studies.