The role of autophagy in modulation of neuroinflammation in microglia. (5th April 2016)

• Record Type: Journal Article
• Authors: Su, P.; Zhang, J.; Wang, D.; Zhao, F.; Cao, Z.; Aschner, M.; Luo, W.
• Is Part Of: Neuroscience. Volume 319(2016)
• Page Start: 155
• Page End: 167
• Publication Date: 2016-04-05
• Subjects: 3-MA 3-methyladenine -- ACAT1 Acyl-CoA:cholesterol acyltransferase 1 -- AD Alzheimer's disease -- Atg autophagy-related protein -- AVs autophagic vesicles -- Aβ amyloid beta -- BCAS bilateral common carotid artery stenosis -- CB2R cannabinoid receptor 2 -- CMA chaperone-mediated autophagy -- CNS central nervous system -- ERK extracellular signal-regulated kinase -- ES electric stimulation -- HANDs HIV-1-associated neurocognitive disorders -- HIF-1α hypoxia-inducible factor 1 alpha -- ICH intracerebral hemorrhage -- IL-1β interleukin-1β -- LAMP2A lysosomal-associated membrane protein type 2A -- LPS lipopolysaccharide -- LRRK2 Leucine rich repeat kinase 2 -- M-CSFR macrophage colony stimulating factor receptor -- NF-κB nuclear factor κB -- PD Parkinson's disease -- PGN peptidoglycan -- pMCAO permanent middle cerebral artery occlusion -- PUMA p53 up-regulated modulator of apoptosis -- SCI spinal cord injury -- shRNA small hairpin RNA -- smTN submedial thalamus nucleus -- Tat HIV-1 trans activator of transcription -- TBI traumatic brain injury -- TLR2 toll-like receptor 2 -- TNF-α tumor necrosis factor-α -- UPS ubiquitin-proteasomal system; microglia -- inflammation -- autophagy; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2016.01.035
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Microglial autophagy can influence the inflammatory response and survival of microglia. Microglial autophagy may be pro-inflammatory or anti- inflammatory. Many mechanisms involved in mediating the process of microglial autophagy. Abstract: Microglia have multiple functions in regulating homeostasis in the central nervous system (CNS), and microglial inflammation is thought to play a role in the etiology of the neurodegenerative diseases. When endogenous or exogenous stimuli trigger disorders in microenvironmental homeostasis in CNS, microglia critically determine the fate of other neural cells. Recently, it was reported that autophagy might influence inflammation and activation of microglia. Though the interaction between autophagy and macrophages has been reported and reviewed in length, the role of autophagy in microglia has yet to be reviewed. Herein, we will highlight recent advances on the emerging role of autophagy in microglia, focusing on the regulation of autophagy during microglial inflammation, and the possible mechanism involved.