Four new steroid saponins with highly oxidized side chains from the leaves of Vernonia amygdalina. (March 2016)

• Record Type: Journal Article
• Authors: Quasie, Olga; Zhang, Yang-Mei; Zhang, Hong-Jian; Luo, Jun; Kong, Ling-Yi
• Is Part Of: Phytochemistry letters. Volume 15(2016:Mar.)
• Page Start: 16
• Page End: 20
• Publication Date: 2016-03
• Subjects: Vernonia amygdalina -- Asteraceae -- C-29 steroid saponins -- Anti-inflammatory; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2015.11.002
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: We isolated four new Δ 7, 9(11) stigmastane-type steroid saponins from an African medicinal plant, Vernonia amygdalina . These compounds possessed highly oxidized side chains. We report that these compounds possess anti-inflammatory activities. Abstract: Vernoamyosides A–D (1–4 ), four new Δ 7, 9(11) stigmastane-type steroid saponins were isolated from the dried leaves of an African medicinal plant Vernonia amygdalina Delile (Asteraceae). Their structures were determined by a combination of spectroscopic analyses (HR-ESI–MS, 1D/2D NMR) and by chemical methods. These four new compounds possessed highly oxidized side chains (C-20–C-29), and formed complex ring systems in2–4 . The inhibitory effects on NO production in lipopolysaccharide-activated RAW264.7 macrophages of these new compounds were tested.