New metabolites from the alga-derived fungi Penicillium thomii Maire and Penicillium lividum Westling. (March 2016)

• Record Type: Journal Article
• Authors: Sobolevskaya, Maria P.; Zhuravleva, Olesya I.; Leshchenko, Elena V.; Zakharenko, Alexander M.; Denisenko, Vladimir A.; Kirichuk, Natalya N.; Popov, Roman S.; Berdyshev, Dmitrii V.; Pislyagin, Evgeny A.; Pivkin, Mikhael V.; Afiyatullov, Shamil Sh.
• Is Part Of: Phytochemistry letters. Volume 15(2016:Mar.)
• Page Start: 7
• Page End: 12
• Publication Date: 2016-03
• Subjects: endo-1, 3-β-d-Glucanase -- Austalides -- Meroterpenoids; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2015.10.016
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Four new metabolites were isolated from the marine fungi P. thomii and P. lividum . The structures of compounds were elucidated by 2D NMR and HR-ESI-MS. The derivatives were assayed for their cytotoxic activity against mouse splenocytes. Some of compounds inhibited endo -1, 3-β-d -Glucanase from mollusk P. sachalinensis . Abstract: A new meroterpenoid, austalide H acid ethyl ester (1 ), 5-(2′, 4′-dihydroxy-6′-methylphenyl)-3-methylfuran-2-carboxylic acid (2 ), 5-(2′-hydroxy-6′-methylphenyl)-3-methylfuran-2-carboxylic acid (3 ) and 5-((6′-methyl-4′-oxo-3′, 4′-dihydro-2 H -pyran-2′-yl)methyl)-3-methylfuran-2-carboxylic acid (4 ), along with six known compounds, austalides H, J, K, and P (5 –8 ), questin (9 ) and sulochrin (10 ) were isolated from the lipophilic extract of the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. The structures of the isolated compounds were determined based on spectroscopic methods. The austalides showed significant inhibitory activity against endo -1, 3-β-d -Glucanase from a crystalline stalk of the marine mollusk Pseudocardium sachalinensis .