Different calorie restriction treatments have similar anti-seizure efficacy. (February 2016)

• Record Type: Journal Article
• Authors: Viggiano, Andrea; Pilla, Raffaele; Arnold, Patrick; Monda, Marcellino; D'Agostino, Dominic; Zeppa, Pio; Coppola, Giangennaro
• Is Part Of: Seizure. Volume 35(2016)
• Page Start: 45
• Page End: 49
• Publication Date: 2016-02
• Subjects: Calorie restriction -- Ketogenic diet -- Synthetic ketone -- Seizure; Epilepsy -- Periodicals; Epilepsy -- Periodicals; Seizures -- Periodicals; Épilepsie -- Périodiques; Electronic journals; Electronic journals; 616.853
• DOI: 10.1016/j.seizure.2016.01.003
• Languages: English
• ISSNs: 1059-1311

Abstract

Graphical abstract: Highlights: The anti-seizure efficacy of a prolonged administration of a synthetic ketone has been evaluated. The prolonged administration of 1, 3-butanediol acetoacetate diester by gavage produces calorie restriction in rats. Gavage treatments in rats produce calorie restriction and anti-seizure effects similar to that of a ketogenic diet. Abstract: Purpose: Previous studies showed that a single oral administration of a synthetic ketone ester (1, 3-butanediol acetoacetate diester, BD-AcAc2 ) could elevate blood ketones with promising acute anti-epileptic effects. The aim of the present work was to evaluate the tolerability of a prolonged administration of BD-AcAc2 and the anti-epileptic efficacy of such treatment. Methods: The threshold for seizure induction with progressive intravenous infusion of pentylenetrazole (PTZ) was evaluated in anesthetized Wistar rats after a ten-day oral administration of BD-AcAc2 (gavage). The effects of this treatment were compared to those of: (1) a ten-day water gavage administration, (2) a ten-day ketogenic diet, (3) a standard rodent chow diet. Results: Compared to the standard diet, all other treatments produced a calorie restriction and an elevation of the seizure threshold. Conclusion: These results indicate that supplementation with an oral synthetic ketone can have anti-seizure effects, but the formulation has to be further ameliorated to be more palatable; further studies are also needed to better understand the role played by ketone bodies alone in vivo, without any calorie restriction.