New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk. Issue 8 (15th April 2016)

• Record Type: Journal Article
• Authors: Li, Yan; Yili, Abulimiti; Li, Jun; Muhamat, Aziz; Aisa, Haji Akber
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 8(2016)
• Page Start: 1983
• Page End: 1987
• Publication Date: 2016-04-15
• Subjects: Fritillaria pallidiflora -- Isosteroidal alkaloid -- Yibeinones A–D -- Tracheal relaxant effect; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2016.03.001
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Four new isosteroidal alkaloids, yibeinones A–D (1 –4 ), along with four known ones, imperialine-3β-d -glucoside (5 ), imperialine (6 ), imperialine β- N -oxide (7 ), and dongbeinine (8 ), were isolated from the bulbs of Fritillaria pallidiflora . Compounds2, 3, 4, and6 showed an apparent concentration-dependant relaxation of isolated tracheal preparation. Abstract: Four new isosteroidal alkaloids, yibeinones A–D (1 –4 ), along with four known ones, imperialine-3β-d -glucoside (5 ), imperialine (6 ), imperialine β- N -oxide (7 ), and dongbeinine (8 ), were isolated from the bulbs of Fritillaria pallidiflora . Their structures were confirmed on the basis of extensive spectroscopic analysis or comparison with the data in the literatures (known compounds). Compounds2, 3, 4, and6 showed an apparent concentration-dependant relaxation of isolated tracheal preparation, amongst3 and6 exhibited significant effects with pA2 values of 6.19 ± 0.02 and 8.41 ± 0.10, and EC50 values of 0.65 ± 0.02 μmol L −1 and 4.40 ± 0.90 nmol L −1, respectively.