Cross‐talk between circadian clocks, sleep‐wake cycles, and metabolic networks: Dispelling the darkness. (11th February 2016)

• Record Type: Journal Article
• Authors: Ray, Sandipan; Reddy, Akhilesh B.
• Is Part Of: BioEssays. Volume 38:Number 4(2016:Apr.)
• Page Start: 394
• Page End: 405
• Publication Date: 2016-02-11
• Subjects: circadian rhythms -- metabolic networks -- non‐transcriptional oscillator -- peroxiredoxin -- redox regulation -- sleep‐wake cycle -- systems biology; Molecular biology -- Periodicals; Cytology -- Periodicals; Developmental biology -- Periodicals; 572.8
• DOI: 10.1002/bies.201500056
• Languages: English
• ISSNs: 0265-9247

Abstract

Abstract : Integration of knowledge concerning circadian rhythms, metabolic networks, and sleep‐wake cycles is imperative for unraveling the mysteries of biological cycles and their underlying mechanisms. During the last decade, enormous progress in circadian biology research has provided a plethora of new insights into the molecular architecture of circadian clocks. However, the recent identification of autonomous redox oscillations in cells has expanded our view of the clockwork beyond conventional transcription/translation feedback loop models, which have been dominant since the first circadian period mutants were identified in fruit fly. Consequently, non‐transcriptional timekeeping mechanisms have been proposed, and the antioxidant peroxiredoxin proteins have been identified as conserved markers for 24‐hour rhythms. Here, we review recent advances in our understanding of interdependencies amongst circadian rhythms, sleep homeostasis, redox cycles, and other cellular metabolic networks. We speculate that systems‐level investigations implementing integrated multi‐omics approaches could provide novel mechanistic insights into the connectivity between daily cycles and metabolic systems. Abstract : The precise mechanisms by which sleep‐wake centers, circadian clocks, and metabolic pathways communicate with each other have not been clearly established. Interaction between non‐transcriptional oscillators and transcription‐translation feedback loop‐based oscillators is also largely obscure. Systems‐level investigations could provide novel mechanistic insights into the connectivity among these complex biological processes.