Back Cover: Biodegradable Inorganic Nanovector: Passive versus Active Tumor Targeting in siRNA Transportation (Angew. Chem. Int. Ed. 14/2016). Issue 14 (8th March 2016)

• Record Type: Journal Article
• Authors: Park, Dae‐Hwan; Cho, Jaeyong; Kwon, Oh‐Joon; Yun, Chae‐Ok; Choy, Jin‐Ho
• Is Part Of: Angewandte Chemie international edition. Volume 55:Issue 14(2016)
• Page Start: 4612
• Page End: 4612
• Publication Date: 2016-03-08
• Subjects: cancer therapy -- inorganic nanovectors -- nanoparticles -- layered compounds -- siRNA delivery; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201602010
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Layered double hydroxide nanovectors conjugated with targeting ligands and loaded with therapeutic siRNA are delivered into tumor tissues and cancer cells by exploiting the enhanced permeability and retention effect and ligand‐receptor interactions. In their Communication onpage 4582 ff. J.‐H. Choy et al. report the inhibition of in vivo tumor growth and suppression of specific gene products through the biodegradable inorganic LDHs.