Highly Enantioselective Rhodium‐Catalyzed Addition of Arylboroxines to Simple Aryl Ketones: Efficient Synthesis of Escitalopram. (2nd March 2016)

• Record Type: Journal Article
• Authors: Huang, Linwei; Zhu, Jinbin; Jiao, Guangjun; Wang, Zheng; Yu, Xingxin; Deng, Wei‐Ping; Tang, Wenjun
• Is Part Of: Angewandte Chemie. Volume 128:Number 14(2016)
• Page Start: 4603
• Page End: 4607
• Publication Date: 2016-03-02
• Subjects: Asymmetrische Katalyse -- Enantioselektivität -- Ligandendesign -- Rhodium -- Totalsynthesen; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201600979
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Highly enantioselective additions of arylboroxines to simple aryl ketones have been achieved for the first time with a Rh/( R, R, R, R )‐WingPhos catalyst, thus providing a range of chiral diaryl alkyl carbinols with excellent ee values and yields. ( R, R, R, R )‐WingPhos has been proven to be crucial for the high reactivity and enantioselectivity. The method has enabled a new, concise, and enantioselective synthesis of the antidepressant drug escitalopram.