An Efficient and Modular Route to Sequence‐Defined Polymers Appended to DNA1. Issue 18 (26th March 2014)

• Record Type: Journal Article
• Authors: Edwardson, Thomas G. W.; Carneiro, Karina M. M.; Serpell, Christopher J.; Sleiman, Hanadi F.
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 18(2014)
• Page Start: 4567
• Page End: 4571
• Publication Date: 2014-03-26
• Subjects: amphiphiles -- DNA -- polymers -- self‐assembly -- solid‐phase synthesis; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201310937
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Inspired by biological polymers, sequence‐controlled synthetic polymers are highly promising materials that integrate the robustness of synthetic systems with the information‐derived activity of biological counterparts. Polymer–biopolymer conjugates are often targeted to achieve this union; however, their synthesis remains challenging. We report a stepwise solid‐phase approach for the generation of completely monodisperse and sequence‐defined DNA–polymer conjugates using readily available reagents. These polymeric modifications to DNA display self‐assembly and encapsulation behavior—as evidenced by HPLC, dynamic light scattering, and fluorescence studies—which is highly dependent on sequence order. The method is general and has the potential to make DNA–polymer conjugates and sequence‐defined polymers widely available. Abstract : Bilingual : A stepwise solid‐phase synthesis approach provides easy access to sequence‐controlled polymers attached to DNA. Polymers with the same molecular composition but different monomer patterns exhibit different amphiphilic self‐assembly. The DNA component still retains base‐pairing fidelity, and thus one molecule "speaks" two orthogonal and programmable assembly languages.